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KMID : 1161320210360040167
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Journal of Animal Reproduciton and Biotechnology
2021 Volume.36 No. 4 p.167 ~ p.174
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Activating and inactivating mutations of the human, rat, equine and eel luteinizing hormone/ chorionic gonadotropin receptors (LH/CGRs)
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Min Kwan-Sik
Byambaragchaa Munkhzaya
Choi Seung-Hee
Joo Hyo-Eun
Kim Sang-Gwon
Kim Yean-Ji
Park Gyeong-Eun
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Abstract
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Mutations in the luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs), representatives of the G protein-coupled receptor family, have been rapidly identified over the last 20 years. This review aims to compare and analyze the data reported the activating and inactivating mutations of the LH/CGRs between human, rat, equine and fish, specifically (Japanese eel Anguilla japonica). Insights obtained through detailed study of these naturally-occurring mutations provide a further update of structure-function relationship of these receptors. Specifically, we present a variety of data on eel LH/CGR. These results provide important information about LH/CGR function in fish and the regulation of mutations of the highly conserved amino acids in glycoprotein hormone receptors.
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KEYWORD
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activating LH/CG receptor, fish (eel), inactivating LH/CGR, mammalian
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